Computing for Cures
Computing for Cures

Foundational partnership with Paradigm4 enables Alnylam Pharmaceuticals to rapidly accelerate RNAi- based drug target discovery.

October 25, 2022 | Paradigm4’s REVEAL Integrative Analytics platform enables Alnylam Pharmaceuticals to discover novel, genetically-validated drug targets from population scale biobank genotype-phenotype datasets and underlies the extraordinary pace and productivity of Alnylam’s RNAi therapeutics pipeline.

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“The scale and pace in growth of human genetics data is an extraordinary semantic and computational challenge. We continue to marvel at Paradigm4’s ability to manage the ever-growing complexities in the day-to-day work of incorporating new genetics tool sets and the constant expansion of novel, diverse phenotypic data.  We endeavour to be the leaders in developing genetically validated RNAi therapeutics and the REVEAL platform has made this possible.”

— Greg Hinkle, VP of Research Informatics, Alnylam

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An Integrative Analytics Software Platform:

  • Build decisive evidence for target identification, biomarkers, and precision medicine using multimodal data
  • Simplify cross-study analysis; streamlines translational research
  • FAIR data access and elastically scalable computation

REVEAL

Life Science Solutions           LEARN MORE

Agile translational research with a suite of extensible, user-friendly apps.

REVEAL Biobank
REVEAL Biobank
Dynamically build custom phenotypes. Seamlessly compute population-scale GWAS.
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REVEAL Single Cell
REVEAL Single Cell
Streamline cross-study, scalable analysis of multi-omics single-cell datasets and atlases.
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REVEAL Multi-omics
REVEAL Multi-omics
FAIR data management with fast scalable analytics across clinical and public studies.
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REVEAL Digital
REVEAL Digital
Agile co-analysis of thousands of hours of data from diverse sensors and video.
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REVEAL Imaging
REVEAL Imaging
Explore and run machine-learning on MRI, mass-spec, FLIM, FISH, and other datasets.
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REVEAL Analytical Development
REVEAL Analytical Development
Unlock CQAs from Allotrope data with high performance data processing and analysis pipelines.
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“P4’s pQTL ran 40x faster and cost 30x less than the consortium’s run. [This] “Highlights the importance not just of biology but also computer science—your knowledge and ability to optimize is also key.”

— Principal Scientist, Computational Genomics, Top 10 Pharma

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Agility Delivered

“The most advanced solution we have to bring together multiple data types and give easy access across all to our researchers… It’s refreshing when it just works.”

— Translational Medicine Bioinformatics Group Lead, Top 10 Pharma